Educational guide 2023_24 Facultade de Química

Contents

Topic	Sub-topic
Subject 1. General aspects of Therapeutic Chemistry	1.1. Concept and objectives of Therapeutic Chemistry. 1.2. Drug nomenclature systems. 1.3. Drug classification systems.
Subject 2. Drug targets: proteins	2.1. Types of drug targets and location. 2.2. Drug-target interactions. 2.3. Transport proteins as drug targets. 2.4. Structural proteins as drug targets.
Subject 3. Drug targets: enzymes	3.1. Enzyme inhibition mechanisms. 3.2. Design of enzyme inhibitors and types of enzyme inhibitors with therapeutic application. 3.3. Isoenzymes as drug targets. 3.4. Measurement and expression of enzyme inhibition.
Subject 4. Receptors	4.1. Stucture and function of receptors. 4.2. Receptor types and signal transduction mechanisms. 4.3. Agonist, antagonist and inverse agonist drugs. 4.4. Measurement and expression of pharmacological effect.
Subject 5. Drug targets: nucleic acids and other biomolecules	5.1. Nucleic acids as drug targets 5.2. Lipids and carbohydrates as drug targets
Subject 5. Nucleic acids and other biomolecules as drug targets	5.1. Mechanisms of interaction between drugs and nucleic acids. 5.2. Lipids and carbohydrates as drug targets.
Subject 6. Pharmacokinetics and related topics	6.1. Absortion and distribution: mechanisms of transport across biological membranes. 6.2. Drug administration ways. 6.3. Drug metabolism. 6.4. Drug excretion.
Subject 7. Drug discovery and development	7.1. The process of obtaining and getting new drugs to the market. 7.2. Lead discovery and optimization strategies.
Subject 8. Rational drug design	8.1. Biochemical based drug design approaches. 8.2. Computational aided drug design: docking and QSAR strategies, pharmacophore based drug design approach.